Nifedipine and diltiazem are calcium channel blockers. They are usually taken as pills to lower blood pressure. But these medicines can also help heal anal fissures. Anal Fissures: Nifedipine and Diltiazem - References. Articles On Anal Fissures: Nifedipine and Diltiazem Anal Fissure and Fistula;. Nifedipine (% to % gel) and diltiazem (2% cream) decrease mean anal resting pressure and improve fissure healing. 18,19 Several studies suggest that topical CCBs are as effective as GTN and have fewer side effects. CONCLUSION: This study shows that topical 2% diltiazem is an effective and safe treatment for chronic anal fissure in patients who have failed topical % GTN. The need for sphincterotomy can be avoided in up to 70% of cases. My surgeon has prescribed me to use diltiazem with 2% for the internal anal fissure. I continously used it, initially it helped to reduce the pain but the pain wasnt gone anywhere. Then i started to get itch in the anal area.
Diltiazem hydrochloride 2% cream is used to promote the healing and reduce symptoms of an anal fissure. An anal fissure is a tear in the skin of . Diltiazem also enhances the analgesic effect of morphine in animal tests, without increasing respiratory depression, and reduces the development of tolerance. Diltiazem is also being used in the treatment of anal fissures. Anal Fissures: Nifedipine and Diltiazem - References. Articles On Anal Fissures: Nifedipine and Diltiazem Anal Fissure and Fistula;.